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Downward dose adjustment of those drugs may very well be required when presented concomitantly with methylphenidate. It may be necessary to change the dosage and keep track of plasma drug concentrations (or, in the situation of coumarin, coagulation occasions), when initiating or discontinuing concomitant methylphenidate.CONCERTA works by using osm

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Withdrawal signals and signs just after abrupt discontinuation or dose reduction adhering to extended utilization of CNS stimulants like CONCERTA incorporate dysphoric temper; melancholy; fatigue; vivid, uncomfortable goals; sleeplessness or hypersomnia; improved urge for food; and psychomotor retardation or agitation.As noted inside the Box Warnin

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